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Related Experiment Video

Updated: Jul 12, 2026

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

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How Layer-Specific fMRI Can Contribute to Understanding Perceptual Disturbances Across Psychiatric Disorders.

Joost Haarsma¹, Peter Kok²

¹Department of Imaging Neuroscience, UCL Queen Square Institute of Neurology, University College London, London, UK. j.haarsma@ucl.ac.uk.

Current Topics in Behavioral Neurosciences

|July 11, 2025

Summary

Layer-specific functional magnetic resonance imaging (fMRI) may unlock new insights into perceptual disturbances by examining how brain layers integrate internal signals with sensory evidence. This approach could reveal mechanisms behind conditions like psychiatric and neurological disorders.

Keywords:

Hallucinations Layer-fMRI Precision-psychiatry Predictive coding

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Area of Science:

Neuroscience
Cognitive Science
Psychiatry
Neurology

Background:

Perceptual disturbances are common in psychiatric and neurological conditions, causing significant distress.
Current understanding of the neural mechanisms underlying these disturbances is limited despite extensive research.
These disturbances may arise from altered integration of internal signals (memory, prediction) with sensory evidence.

Purpose of the Study:

To explore the potential of layer-specific functional magnetic resonance imaging (fMRI) for understanding perceptual disturbances.
To investigate how neural integration across cortical layers contributes to perceptual disturbances.
To identify mechanisms driving disruptions in integrating internal and sensory information.

Main Methods:

Review of recent findings utilizing layer-specific fMRI.
Exploration of how neural computations in different cortical layers relate to perceptual disturbances.
Discussion of pharmacological layer-specific fMRI as a future research tool.

Main Results:

Emerging evidence suggests key neural computations for integrating internal and sensory signals are layer-dependent.
Layer-specific fMRI shows promise in identifying the mechanisms underlying perceptual disturbances.
Pharmacological fMRI could further enhance understanding of layer-specific neural processes.

Conclusions:

Layer-specific fMRI offers a novel approach to investigate the neural basis of perceptual disturbances.
Understanding layer-specific computations is crucial for elucidating the mechanisms of these distressing phenomena.
Further research, including pharmacological fMRI, is needed to overcome current limitations and advance the field.