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Related Experiment Videos

Contact sensitivity to chlorhexidine?

E Bechgaard, E Ploug, N Hjorth

    Contact Dermatitis
    |August 1, 1985
    PubMed
    Summary

    Chlorhexidine gluconate patch testing revealed a 2.3% positive reaction rate. Eczema and leg ulcer patients showed higher rates, suggesting potential false positives from the excited skin syndrome.

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    Area of Science:

    • Dermatology
    • Allergology
    • Clinical Toxicology

    Background:

    • Chlorhexidine gluconate is a widely used antiseptic.
    • Patch testing is a standard method for diagnosing allergic contact dermatitis.
    • The excited skin syndrome can cause false positive patch test reactions.

    Purpose of the Study:

    • To evaluate the prevalence of chlorhexidine gluconate allergy.
    • To investigate the influence of leg eczema and leg ulcers on patch test results.
    • To assess the potential for false positive reactions in patients with compromised skin.

    Main Methods:

    • A prospective study involving 2061 patients patch tested with chlorhexidine gluconate 1% in water.
    • Analysis of reaction rates based on sex and pre-existing skin conditions.
    • Retesting of positive reactors with varying concentrations of chlorhexidine gluconate.

    Main Results:

    • Overall positive reaction rate was 2.3% (48/2061).
    • Higher positive rates were observed in men (3.2%) compared to women (1.9%).
    • Patients with leg eczema (6.8%) and leg ulcers (10.9%) showed the highest positive rates.

    Conclusions:

    • False positive patch test reactions, potentially due to the excited skin syndrome, may occur in patients with eczema or leg ulcers.
    • The sensitizing potential of chlorhexidine gluconate may be low.
    • Further evaluation is needed for chlorhexidine gluconate's potential in patients with leg eczema or ulcers.

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