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Biomedical and Clinical Sciences
Oncology and Carcinogenesis
Predictive and prognostic markers
Cartilage-protective effects of lopinavir/ritonavir: in vitro and in silico exploration of the HIF-1α/SOX9/IL-1β pathway

Cartilage-protective effects of lopinavir/ritonavir: in vitro and in silico exploration of the HIF-1α/SOX9/IL-1β pathway

Hanefi Ozbek ¹, Ibrahim Yilmaz ², Aslı Akyuz ³, Suray Pehlivanoglu ⁴, Duygu Yasar Sirin ³, Mehmet Albayrak ⁵, Omer Faruk Yilmaz ⁶

Hanefi Ozbek ¹, Ibrahim Yilmaz ², Aslı Akyuz ³

¹Department of Medical Pharmacology, Usak University School of Medicine, Usak, 64200, Turkey. hanefi.ozbek@usak.edu.tr.
²Unit of Pharmacovigilance, Republic of Turkey, Ministry of Health, Dr. Ismail Fehmi Cumalioglu City Hospital, Tekirdag, 59020, Turkey.
³Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Namik Kemal University, Tekirdag, 59100, Turkey.
⁴Department of Molecular Biology and Genetics, Faculty of Arts and Sciences, Necmettin Erbakan University, Konya, 42090, Turkey.
⁵Department of Medical Services and Techniques, Vocational School of Health Services, Istanbul Rumeli University, Istanbul, 34570, Turkey.
⁶Clinics of Orthopaedic and Traumatology, Republic of Turkey, Ministry of Health, Corlu State Hospital, Tekirdag, 59850, Turkey.

⁰Department of Medical Pharmacology, Usak University School of Medicine, Usak, 64200, Turkey. hanefi.ozbek@usak.edu.tr.

Journal of Orthopaedic Surgery and Research +

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July 11, 2025

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July 11, 2025

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Summary

No abstract available on PubMed

Keywords:

Chondrocyte HIF-1α Il-1β Lopinavir/ritonavir SOX9

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