Sex Differences in Associations of Lewy Body Disease with Alzheimer's Disease and Cognitive Decline
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View abstract on PubMed
Summary
This summary is machine-generated.Sex influences Alzheimer's disease (AD) and Lewy body disease (LBD) neuropathologies. Earlier menopause in women exacerbates LBD effects on neurofibrillary tangles and memory decline.
Area Of Science
- Neuropathology
- Neuroscience
- Gerontology
Background
- Alzheimer's disease (AD) and Lewy body disease (LBD) are common neurodegenerative disorders.
- The interplay between AD and LBD neuropathologies and their differential impact based on sex and menopausal status is not fully understood.
Purpose Of The Study
- To investigate how sex and age at menopause influence the interplay between AD and LBD neuropathologies.
- To examine the associations of these neuropathologies with cognitive decline.
Main Methods
- Analysis of three Rush Alzheimer's Disease Center cohorts and the National Alzheimer's Coordinating Center Neuropathology Data Set.
- Neuropathological evaluation of LBD, AD, neuritic plaques, and neurofibrillary tangles.
- Testing interactive associations between LBD, sex, and menopausal age with neuropathologies and cognitive decline.
Main Results
- Men were more likely to have LBD, while women had greater neuritic plaque and neurofibrillary tangle burdens.
- Sex modified LBD associations with neurofibrillary tangles, being stronger in women.
- Earlier menopause in women exacerbated LBD's link to neurofibrillary tangles and episodic memory decline.
Conclusions
- Sex significantly influences AD and LBD neuropathological profiles.
- Age at menopause is a critical factor in women's susceptibility to LBD-related neuropathology and cognitive decline.
- Findings underscore the need for sex-specific and personalized approaches in dementia prevention and treatment.
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