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Enteric Delivery of Probiotics: Challenges, Techniques, and Activity Assays
Chunying Sun1, Zhidong Zhang1, Yantong Sun1
1State Key Laboratory of Food Nutrition and Safety, Food Biotechnology Engineering Research Center of Ministry of Education, College of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin 300457, China.
Foods (Basel, Switzerland)
|July 12, 2025
Summary
Innovative delivery systems enhance probiotic survival and gut colonization. These advanced methods, including nanocoatings and microgels, overcome challenges for improved gastrointestinal health.
Area of Science:
- Microbiology
- Biotechnology
- Food Science
Background:
- Probiotics are live microorganisms crucial for gut health and immunity.
- Challenges include probiotic inactivation and poor gut colonization.
- Effective delivery systems are needed to overcome these limitations.
Purpose of the Study:
- To review recent advances in probiotic delivery systems.
- To analyze innovative technologies for enhanced probiotic viability and delivery.
- To discuss the potential of these systems in modulating gut microbiota.
Main Methods:
- Review of hydrogels, nanocoatings, emulsions, and core-shell microgels.
- Analysis of polyphenol-based nanocoatings and metal-phenolic networks (MPNs).
- Exploration of microalgae-based bio-carriers for targeted delivery.
Main Results:
- Edible delivery systems can preserve probiotic viability and enable controlled release.
- Nanocoatings and MPN encapsulation enhance bacterial survival rates.
- Microalgae carriers show potential for targeted probiotic delivery.
Conclusions:
- Advanced delivery systems offer novel strategies for a healthy gut microbiome.
- These systems can improve probiotic activity and gut colonization.
- Further research is needed to address safety, scalability, and clinical translation.
