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Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
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Novel Strategies and Therapeutic Advances for Bladder Cancer
Matthew I Ehrlich1, Robert D Fox1, Karie D Runcie1
1Division of Hematology & Oncology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Cancers
|July 12, 2025
Summary
Novel treatments are rapidly changing bladder cancer care. Research focuses on bladder-sparing options for muscle-invasive bladder cancer (MIBC) and advanced therapies for metastatic disease.
Area of Science:
- Oncology
- Urology
Background:
- Bladder cancer treatment has seen significant advancements.
- Novel therapeutic strategies are emerging for various stages of bladder cancer.
Purpose of the Study:
- To review recent clinical trials and therapeutic advances in bladder cancer treatment.
- To summarize novel strategies and ongoing research in bladder cancer therapy.
Main Methods:
- Comprehensive literature review of recent and ongoing clinical trials (2020 onwards).
- Focus on novel treatments and therapeutic strategies for bladder cancer.
Main Results:
- For muscle-invasive bladder cancer (MIBC), neoadjuvant chemotherapy with perioperative immunotherapy is standard for cisplatin-eligible patients; guidelines are lacking for cisplatin-ineligible patients.
- Investigational strategies for MIBC include combinations of chemotherapy, immunotherapy, radiation, antibody-drug conjugates (ADCs), targeted agents, intravesical treatments, and personalized vaccines, with bladder-sparing approaches being studied.
- In advanced/metastatic settings, enfortumab vedotin plus pembrolizumab is now first-line, replacing platinum-based chemotherapy. Investigational options for progression include newer immunotherapies, ADCs, small molecule inhibitors, and cellular therapies.
Conclusions:
- The therapeutic landscape for bladder cancer has dramatically evolved recently.
- Ongoing trials aim to establish bladder-sparing approaches for MIBC and novel systemic therapies for advanced disease.
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