Diagnostic and Therapeutic Potential of Selected microRNAs in Colorectal Cancer: A Literature Review
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View abstract on PubMed
Summary
This summary is machine-generated.MicroRNAs (miRNAs) are key biomarkers for monitoring colorectal cancer. This review details their diagnostic potential and therapeutic applications, highlighting their role in cancer progression and treatment sensitivity.
Area Of Science
- Oncology
- Molecular Biology
- Genetics
Background
- Colorectal cancer remains a leading cause of cancer incidence and mortality globally.
- MicroRNAs (miRNAs) are increasingly recognized as critical biomarkers due to their stability and detectability in biological fluids.
Purpose Of The Study
- To review deregulated miRNAs in colorectal cancer.
- To explore their diagnostic and prognostic value.
- To highlight their therapeutic potential in cancer management.
Main Methods
- Literature review of studies on microRNA deregulation in colorectal cancer.
- Analysis of specific miRNAs including miR-21, miR-29b, miR-148a, miR-149, miR-155, miR-194, miR-200b, miR-6803-5p, and miR-4772-3p.
- Examination of miRNA involvement in key cancer pathways (Wnt/β-catenin, PI3K/Akt, EGFR) and their impact on proliferation, migration, and treatment response.
Main Results
- Selected miRNAs are deregulated in colorectal cancer, correlating with abnormal cell proliferation, migration, and microenvironment changes.
- miRNA dysregulation impacts response to therapies like 5-FU and oxaliplatin.
- Specific miRNAs show potential in modulating tumor sensitivity to chemotherapy.
Conclusions
- MicroRNAs are promising non-invasive diagnostic and prognostic biomarkers for colorectal cancer.
- Targeting miRNAs offers a potential therapeutic strategy to enhance treatment efficacy and overcome resistance.
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