Related Experiment Video
Updated: Sep 16, 2025
06:46
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
380
Risk Factors of Multiple Primary Cancers Among Colorectal Cancer Survivors
Mulugeta Melku1,2, Oliver G Best1, Jean M Winter1
1Flinders Health and Medical Research Institute, College of Medicine and Public Health, Flinders University, Bedford Park, SA 5042, Australia.
Cancers
|July 12, 2025
Summary
Colorectal cancer survivors have a higher risk of developing subsequent cancers. Male sex, older age, early-stage cancer, and loss of mismatch repair protein expression are key risk factors for these multiple primary cancers.
Area of Science:
- Oncology
- Cancer Epidemiology
Background:
- Colorectal cancer (CRC) is a leading global cause of cancer-related death.
- CRC survivors face an increased risk of developing subsequent multiple primary cancers (MPCs).
Purpose of the Study:
- To determine the incidence of metachronous MPCs in CRC survivors.
- To identify risk factors associated with the development of MPCs in this population.
Main Methods:
- Retrospective analysis of 554 CRC patients diagnosed between 2011 and 2024.
- Utilized cumulative incidence function and sub-distribution hazard models.
- Collected sociodemographic, clinical, tumor, and treatment data.
Main Results:
- 12% of CRC survivors developed MPCs within a median follow-up of 5 years.
- Cumulative incidence of MPC was 20.9%; standardized incidence ratio (SIR) was 1.32.
- Increased risk associated with male sex, age >65, early-stage cancer, and loss of mismatch repair (MMR) protein expression.
Conclusions:
- CRC survivors exhibit an elevated risk for developing MPCs compared to the general population.
- Identifying risk factors like sex, age, cancer stage, and MMR status is crucial.
- Personalized surveillance strategies are recommended for early detection and improved outcomes.
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