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Related Experiment Video

Updated: Sep 16, 2025

Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection

Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection

Published on: September 21, 2015

EpiSwitch PSE Blood Test Reduces Unnecessary Prostate Biopsies: A Real-World Clinical Utility Study.

Joos Berghausen¹, Joe Abdo², Ryan Mathis²

¹Department of Pharmacology and Physiology, Georgetown University Medical Center, 3900 Reservoir Rd NW, Washington, DC 20057, USA.

|July 12, 2025

Summary

The EpiSwitch PSE assay, a blood test for prostate cancer, can help avoid unnecessary biopsies in up to 79% of men, improving diagnostic efficiency and reducing healthcare costs.

Keywords:

3D genome conformation EpiSwitch PSE assay biopsy avoidance blood-based diagnostics precision oncology prostate cancer detection real-world evidence

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Last Updated: Sep 16, 2025

Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection

Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection

Published on: September 21, 2015

Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance

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Published on: June 6, 2025

Detection and Isolation of Cancer in Prostate Biopsies Using Stimulated Raman Histology and Artificial Intelligence

Detection and Isolation of Cancer in Prostate Biopsies Using Stimulated Raman Histology and Artificial Intelligence

Published on: June 10, 2025

Area of Science:

Oncology
Genomics
Diagnostic Medicine

Background:

Prostate cancer (PCa) diagnosis relies on PSA screening, which has low specificity and sensitivity.
Current methods lead to unnecessary invasive procedures and increased healthcare costs.

Purpose of the Study:

Evaluate the EpiSwitch PSE assay for avoiding unnecessary prostate cancer biopsies.
Assess the clinical and economic benefits of the EpiSwitch PSE assay.

Main Methods:

187 patients evaluated for PCa underwent the EpiSwitch PSE assay.
Predictive modeling used PSE results and clinical variables for 134 patients.
Biopsy confirmation was available for 53 patients.

Main Results:

Predictive modeling indicated up to 79.1% biopsy avoidance.
The PSE assay showed strong concordance with biopsy results.
PSE results were the most influential predictor in multivariate analysis.

Conclusions:

The EpiSwitch PSE assay enhances decision-making and reduces unnecessary biopsies.
The assay demonstrates significant clinical utility and economic value.
Potential for broader adoption as a pre-biopsy triage tool for prostate cancer.