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Updated: Sep 16, 2025

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
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CAR-Based Cell Therapy in Head and Neck Cancer: A Comprehensive Review on Clinical Applicability

Francesco Perri1, Margaret Ottaviano2, Miriam Tomaciello3

  • 1Clinical and Experimental Head and Neck Medical Oncology Unit, INT IRCCS Foundation G Pascale, 80131 Naples, Italy.

Cancers
|July 12, 2025
PubMed
Summary

Chimeric antigen receptor T-cell (CAR-T) therapy shows promise for head and neck cancer (HNC). Despite challenges in the immunosuppressive tumor microenvironment, CAR-T cell therapy may offer future clinical applications for HNC management.

Keywords:
CAR-Thead and neck cancerimmune checkpointimmunotherapytumor microenvironment

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