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Related Experiment Video

Updated: Sep 16, 2025

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Integrating Clinical and Transcriptomic Profiles Associated with Vitamin D to Enhance Disease-Free Survival in

Geeitha Senthilkumar1, Renuka Pitchaimuthu1, Seshathiri Dhanasekaran2

  • 1Department of Information Technology, M. Kumarasamy College of Engineering, Thalavapalayam, Karur 639113, Tamil Nadu, India.

Diagnostics (Basel, Switzerland)
|July 12, 2025
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Summary

Higher vitamin D levels correlate with reduced cervical cancer recurrence and improved survival. This study highlights vitamin D

Keywords:
cervical cancer recurrencedisease-free survivallong non-coding RNAmachine learning predictorsvitamin D

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cervical cancer recurrence is a significant clinical challenge.
  • Long non-coding RNAs (lncRNAs) play a role in cancer recurrence.
  • Vitamin D's regulatory role in cervical cancer recurrence warrants investigation.

Purpose of the Study:

  • To investigate vitamin D's regulatory role in cervical cancer recurrence.
  • To identify the involvement of lncRNAs in this process.
  • To analyze clinical data for correlations between vitamin D levels and patient outcomes.

Main Methods:

  • Transcriptomic analysis of CaSki cells using GEO dataset GSE267715.
  • Application of machine learning models (CatBoost, LightGBM, Extra Trees, Logistic Regression).
  • Utilized feature selection methods (ANOVA F-test, mutual information, Chi-squared, RFE) and performance metrics (accuracy, precision, recall, ROC AUC).

Main Results:

  • Clinical data from 738 patients showed higher serum vitamin D linked to lower recurrence and better disease-free survival (DFS).
  • CatBoost model achieved 95.27% accuracy, 0.9930 ROC AUC, 0.9296 precision, and 0.9706 recall.
  • Identified specific genes regulated by vitamin D that may prevent cervical cancer recurrence.

Conclusions:

  • Vitamin D demonstrates therapeutic potential in managing cervical cancer recurrence.
  • lncRNAs emerge as potential therapeutic targets for cervical cancer recurrence.
  • This research provides a foundation for novel therapeutic strategies involving vitamin D and lncRNAs.