Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

678
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
678

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Environmental impacts of single-use versus reusable duodenoscopes for endoscopic retrograde cholangiopancreatography in Germany: an ISO-compliant cradle-to-grave life cycle assessment.

Gut·2026
Same author

Autoimmune Pancreatitis Re-Classification with Novel Type AIP-4.

International journal of molecular sciences·2026
Same author

Diagnosis and Therapy of Endometriosis. Guideline of the DGGG, OEGGG and SGGG (S2k-Level, AWMF Registry No. 015/045, April 2025).

Geburtshilfe und Frauenheilkunde·2026
Same author

Heavy Metals Like Aluminum, Arsenic, Cadmium, Chromium, Copper, Iron, Lead, Manganese, Mercury, Nickel, and Zinc Polluting the Drinking Water: Their Individual Health Hazards.

International journal of molecular sciences·2025
Same author

Intraductal cryobiopsy via percutaneous cholangioscopy for biliary strictures: a multicenter feasibility study.

Endoscopy·2025
Same author

Drug-Induced Autoimmune Hepatitis by Varenicline and Infliximab as a Continuous Disease Spectrum with Two Different Flares: Acute Liver Injury Followed by Hepatic Autoimmunity.

International journal of molecular sciences·2025
Same journal

Correction: Luca et al. Global and Regional Diagnostic Results of Progress Toward Cervical Cancer Elimination, According to the WHO Strategy: A Systematic Literature Review with Narrative Synthesis. <i>Diagnostics</i> 2026, <i>16</i>, 1224.

Diagnostics (Basel, Switzerland)·2026
Same journal

Association Between Systemic Inflammatory Response Biomarkers and Disease Activity in Systemic Lupus Erythematosus: A Multi-Center Retrospective Study.

Diagnostics (Basel, Switzerland)·2026
Same journal

Vertebrogenic Low Back Pain and Basivertebral Nerve Ablation: A Review of Mechanisms, Imaging-Driven Selection, and Clinical Outcomes.

Diagnostics (Basel, Switzerland)·2026
Same journal

Multivalvular Carcinoid Heart Disease: The Role of Echocardiography in Diagnosis and Selection for Heterotopic Bicaval Valve Implantation.

Diagnostics (Basel, Switzerland)·2026
Same journal

Data-Efficient and Explainable Multimodal Survival Prediction in NSCLC Using Deep Image Embeddings, Clinical Variables, and Gradient-Boosted Trees.

Diagnostics (Basel, Switzerland)·2026
Same journal

Anomalous Left Coronary Artery from the Pulmonary Artery: Cinematic Volume Rendering Technique for Enhanced Anatomic Visualization.

Diagnostics (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: Sep 16, 2025

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
11:36

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

3.1K

Drug-Induced Autoimmune Hepatitis: Robust Causality Assessment Using Two Different Validated and Scoring Diagnostic

Rolf Teschke1,2, Axel Eickhoff1,2, Gaby Danan3

  • 1Department of Internal Medicine II, Division of Gastroenterology and Hepatology, Klinikum Hanau, D-63450 Hanau, Germany.

Diagnostics (Basel, Switzerland)
|July 12, 2025
PubMed
Summary
This summary is machine-generated.

Harmonizing causality assessments for drug-induced autoimmune hepatitis (DIAIH) is crucial for accurate diagnosis. Using both RUCAM and simplified AIH scores improves characterization of this liver injury subtype.

Keywords:
DIAIHautoimmune hepatitisidiosyncratic DILIsimplified AIH scoreupdated RUCAM

More Related Videos

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
09:03

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Published on: February 3, 2012

19.4K
Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
26:48

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Published on: July 4, 2007

18.3K

Related Experiment Videos

Last Updated: Sep 16, 2025

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
11:36

Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms

Published on: May 29, 2020

3.1K
The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
09:03

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Published on: February 3, 2012

19.4K
Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
26:48

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Published on: July 4, 2007

18.3K

Area of Science:

  • Hepatology
  • Immunology
  • Pharmacology

Background:

  • Drug-induced autoimmune hepatitis (DIAIH) is an idiosyncratic drug-induced liver injury (iDILI) subtype with variably described features.
  • Inconsistent cohort assessments hinder a clear understanding of DIAIH characteristics.

Purpose of the Study:

  • To harmonize DIAIH cohorts by unifying causality assessment methods.
  • To better characterize the features of DIAIH through standardized diagnostic criteria.

Main Methods:

  • Systematic evaluation of published DIAIH case reports for causality assessment methodologies.
  • Utilizing the Roussel Uclaf Causality Assessment (RUCAM) for the iDILI component.
  • Employing the simplified AIH score for the autoimmune hepatitis component.

Main Results:

  • 60% of reports (12/20) used both RUCAM and simplified AIH score, identifying 49 causative drugs/combinations in 25 DIAIH cases.
  • Elevated ALT levels (up to 3489 UL) and high autoimmune markers supported DIAIH diagnoses.
  • 20% of reports used only RUCAM, 10% used only the simplified AIH score, and 10% used no algorithm, providing insufficient diagnostic criteria.

Conclusions:

  • Concomitant use of RUCAM and simplified AIH score is essential for accurate DIAIH diagnosis and characterization.
  • The term DIAIH should be restricted to drug-induced cases, with alternative terminology proposed for non-drug-induced conditions.
  • Drug cessation and immunotherapy (corticosteroids, azathioprine) are the primary treatments for DIAIH.