Correlation Between MRI Characteristic of Osteosarcoma with 2-Year Survival Outcomes

Area of Science:

• Oncology
• Radiology
• Medical Imaging

Background:

• Magnetic resonance imaging (MRI) is vital for osteosarcoma staging and preoperative assessment.
• Limited research exists on 2-year survival, a key indicator of tumor aggressiveness and early progression.
• This study investigates MRI features associated with 2-year survival in osteosarcoma patients.

Purpose of the Study:

• To identify MRI characteristics that predict 2-year survival in osteosarcoma.
• To understand the imaging features of high-risk osteosarcoma patients.
• To correlate specific MRI findings with patient survival outcomes.

Main Methods:

• Retrospective case-control study of 28 osteosarcoma patients with pre-treatment MRI and ≥2 years follow-up.
• Two blinded radiologists assessed MRI features: tumor volume, skip metastases, fluid-fluid levels, growth pattern, fractures, and involvement of structures.
• Statistical analyses (Fisher's exact, Chi-square, Mann-Whitney U) determined associations between MRI features and 2-year survival.

Main Results:

• Larger tumor volume (>300 mls) was significantly linked to poorer 2-year survival (p=0.008).
• Presence of skip metastases also correlated with worse outcomes (p=0.041).
• Fluid-fluid levels, concentric growth, lymphadenopathy, and physeal involvement showed non-significant trends toward poorer prognosis.

Conclusions:

• MRI tumor volume and skip metastases are significant prognostic indicators for 2-year survival in osteosarcoma.
• These findings support MRI's role in risk stratification and treatment planning for osteosarcoma.
• Identifying high-risk patients via MRI can improve patient management strategies.