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Updated: Sep 16, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
A Comprehensive Review of Explainable Artificial Intelligence (XAI) in Computer Vision
Zhihan Cheng1,2, Yue Wu1,2, Yule Li3,4
1Department of Mathematics, College of Science, Mathematics and Technology, Wenzhou-Kean University, Wenzhou 325060, China.
Explainable Artificial Intelligence (XAI) methods in computer vision are compared. Transformer-based approaches show promise in medical imaging, though careful interpretation is needed.
Area of Science:
- Computer Vision
- Artificial Intelligence
- Explainable AI (XAI)
Background:
- Explainable Artificial Intelligence (XAI) is crucial for understanding complex computer vision models.
- Existing XAI methods lack standardized comparison, hindering effective application.
Purpose of the Study:
- To conduct a comparative analysis of prominent XAI methods in computer vision.
- To evaluate XAI techniques across key metrics and propose a classification system.
Main Methods:
- Categorization of XAI methods into attribution-based, activation-based, perturbation-based, and transformer-based approaches.
- Evaluation using metrics like faithfulness, localization accuracy, efficiency, and overlap with medical annotations.
- Development of a hierarchical taxonomy for classifying XAI techniques.
Main Results:
- Perturbation-based methods (e.g., RISE) demonstrate high faithfulness but are computationally intensive.
- Transformer-based methods achieve high performance in medical imaging tasks (IoU scores).
- No single method excels across all evaluated metrics, highlighting trade-offs.
Conclusions:
- Context-aware evaluation and hybrid XAI approaches are necessary to balance interpretability and efficiency.
- Standardized benchmarks and domain-specific tuning are essential for advancing XAI.
- Addressing ethical and practical challenges is vital for reliable XAI deployment.
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