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Updated: Sep 16, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
A Comprehensive Review of Explainable Artificial Intelligence (XAI) in Computer Vision
Zhihan Cheng1,2, Yue Wu1,2, Yule Li3,4
1Department of Mathematics, College of Science, Mathematics and Technology, Wenzhou-Kean University, Wenzhou 325060, China.
Abstract:
Explainable Artificial Intelligence (XAI) is increasingly important in computer vision, aiming to connect complex model outputs with human understanding. This review provides a focused comparative analysis of representative XAI methods in four main categories, attribution-based, activation-based, perturbation-based, and transformer-based approaches, selected from a broader literature landscape. Attribution-based methods like Grad-CAM highlight key input regions using gradients and feature activation. Activation-based methods analyze the responses of internal neurons or feature maps to identify which parts of the input activate specific layers or units, helping to reveal hierarchical feature representations. Perturbation-based techniques, such as RISE, assess feature importance through input modifications without accessing internal model details. Transformer-based methods, which use self-attention, offer global interpretability by tracing information flow across layers. We evaluate these methods using metrics such as faithfulness, localization accuracy, efficiency, and overlap with medical annotations. We also propose a hierarchical taxonomy to classify these methods, reflecting the diversity of XAI techniques. Results show that RISE has the highest faithfulness but is computationally expensive, limiting its use in real-time scenarios. Transformer-based methods perform well in medical imaging, with high IoU scores, though interpreting attention maps requires care. These findings emphasize the need for context-aware evaluation and hybrid XAI methods balancing interpretability and efficiency. The review ends by discussing ethical and practical challenges, stressing the need for standard benchmarks and domain-specific tuning.
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