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Are Inflammatory Markers and Periodontitis Effective in Predicting Miscarriage?
Isa Temur1, Selcen Ozcan Bulut2, Safak Necati Dönertas2
1Department of Obstetrics and Gynecology, Faculty of Medicine, Niğde Ömer Halisdemir University, 51240 Niğde, Türkiye.
Healthcare (Basel, Switzerland)
|July 12, 2025
Summary
Periodontal disease, indicated by Clinical Attachment Loss (CAL), is a significant predictor of miscarriage risk. Hematological parameters like Plateletcrit (PCT) also show associations, highlighting the link between oral health and pregnancy outcomes.
Area of Science:
- Obstetrics and Gynecology
- Periodontology
- Hematology
- Reproductive Health
Background:
- Miscarriage is a common pregnancy complication with profound physical and psychological impacts.
- Understanding risk factors for miscarriage is crucial for improving maternal and infant outcomes.
- The relationship between periodontal health and pregnancy complications like miscarriage requires further investigation.
Purpose of the Study:
- To investigate the association between periodontal health and hematological parameters in women experiencing miscarriage.
- To assess the predictive value of periodontal and hematological parameters for miscarriage risk.
- To compare these parameters between women with miscarriage and those with uncomplicated pregnancies.
Main Methods:
- Prospective case-control and cross-sectional study involving 82 participants (41 miscarriage, 41 controls).
- Periodontal examinations included Gingival Index (GI), Plaque Index (PI), Probing Depth (PD), Clinical Attachment Loss (CAL), and Simplified Calculus Index (SCI).
- Complete blood counts (CBCs) were analyzed, including Plateletcrit (PCT), Platelet Count (PLT), and Neutrophil-to-Lymphocyte Ratio (NLR). Statistical analyses included logistic regression and ROC analysis.
Main Results:
- Clinical Attachment Loss (CAL) was significantly elevated in the miscarriage group and was the strongest predictor of miscarriage risk (AUC = 0.8691).
- Plateletcrit (PCT) was significantly higher in the miscarriage group and positively correlated with Gingival Index (GI), indicating a link between systemic inflammation and periodontal health.
- Platelet Count (PLT) and PCT demonstrated some discriminative power for miscarriage risk.
Conclusions:
- Clinical Attachment Loss (CAL) is a significant predictor of miscarriage.
- Hematological parameters like Platelet Count (PLT) and Plateletcrit (PCT) show potential in predicting miscarriage risk.
- Collaboration between obstetricians and dentists, along with integrated oral health assessments in prenatal care, is recommended for early diagnosis and intervention.
