Current Unveiling Key Research Trends in Endometrial Cancer: A Comprehensive Topic Modeling Analysis

Area of Science:

• Gynecologic Oncology
• Medical Informatics

Background:

• Endometrial cancer (EC) is a globally prevalent malignancy with increasing incidence.
• Comprehensive reviews of EC research trends are limited.

Purpose of the Study:

• To analyze and classify recent research trends in endometrial cancer using topic modeling.
• To identify key research areas and inform future study directions.

Main Methods:

• Systematic literature search of PubMed, Web of Science, and Cochrane Library (2019-2023).
• Utilized topic modeling and keyword analysis on 2188 selected studies.
• Keywords included 'cancer', 'risk', 'survival', 'stage', 'tumor', 'surgery', and 'OS.'

Main Results:

• Ten research clusters were identified: 'Gynecologic cancer', 'Surgical staging', 'Therapeutic efficacy', 'Diagnosis', 'Surgical management', 'Multimodal treatment', 'Molecular treatment', 'Risk factors', 'Survival', and 'Hormonal regulation.'
• High-frequency keywords highlight focus on surgical decision-making, outcome prediction, and survival.

Conclusions:

• Current endometrial cancer research emphasizes surgical interventions and survival outcomes.
• Future research should prioritize multimodal treatment, risk factor identification for prevention, and enhancing patient quality of life.