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Safe, Smart, and Scalable: A Prospective Multicenter Study on Low-Dose CT and CTSS for Emergency Risk Stratification
Andrzej Górecki1, Piotr Piech2, Anna Bronikowska2
1Medical Diagnostic Center Voxel, Regional Hospital in Łańcut, 37-100 Łańcut, Poland.
Journal of Clinical Medicine
|July 12, 2025
Summary
Low-dose chest CT (LDCT) with a CT severity score (CTSS) effectively identifies high-risk COVID-19 patients for ICU admission and mortality. This rapid imaging tool aids emergency care risk stratification.
Area of Science:
- Radiology
- Emergency Medicine
- Infectious Diseases
Background:
- Effective early risk stratification for COVID-19 is challenging due to RT-PCR limitations.
- There is a need for rapid, reliable, and safe imaging for acute care settings.
Purpose of the Study:
- To evaluate low-dose chest CT (LDCT) and CT severity score (CTSS) for emergency risk stratification in COVID-19.
- To correlate CTSS with clinical outcomes and laboratory markers.
Main Methods:
- Prospective, multicenter study of 555 PCR-confirmed COVID-19 patients.
- Standardized LDCT protocol at admission.
- CTSS calculated for pulmonary involvement, analyzed against ICU admission, mortality, and clinical/lab data.
Main Results:
- CTSS ≥13 and ≥15 significantly associated with ICU admission and mortality (p < 0.01).
- CTSS strongly correlated with CRP, LDH, and dyspnea; negatively with oxygen saturation and lymphocytes.
- Standardized LDCT ensured consistent quality and low radiation exposure.
Conclusions:
- LDCT with CTSS offers a robust, reproducible, radiation-sparing method for COVID-19 emergency risk stratification.
- High clinical utility supports use in triage and future AI-driven diagnostics.
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