International Consensus Guidelines on the Safe and Evidence-Based Practice of Mesotherapy: A Multidisciplinary...

Area of Science:

• Integrative Medicine
• Evidence-Based Practice

Background:

• Mesotherapy is a globally utilized technique lacking standardized, evidence-based protocols.
• Existing practices are often based on personal beliefs rather than scientific validation.

Purpose of the Study:

• To develop internationally recognized, evidence-based standards for mesotherapy.
• To critically evaluate the clinical benefits and limitations of mesotherapy.
• To propose standardized protocols, guidelines, and expert recommendations.

Main Methods:

• Comprehensive literature review of studies from 1976-2023.
• Development of 23 clinical questions based on literature and patient association needs.
• Multi-round expert evaluation and voting by a multidisciplinary international panel.

Main Results:

• Recommendations support mesotherapy use in diverse clinical settings.
• A standardized framework is provided for efficacy and patient safety.
• Guidelines address osteoarticular pain, rehabilitation, and dermatological applications.

Conclusions:

• Mesotherapy practice is transitioning to an evidence-based approach.
• Identified limitations highlight the need for ongoing research.
• Scheduled updates for guidelines are recommended to reflect new evidence.