Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Burn Injuries01:22

Burn Injuries

2.9K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
2.9K
Varicose Veins II: Diagnostic Studies and Interprofessional Care01:26

Varicose Veins II: Diagnostic Studies and Interprofessional Care

35
Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...
35

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Use of Kerecis Omega3 Wound Fish Skin Graft for the Treatment of Deep Burn Wounds.

Plastic and reconstructive surgery. Global open·2026
Same author

The Utility and Applicability of the Modified 5-Item Frailty Index in Cosmetic Surgery.

Aesthetic plastic surgery·2026
Same author

Time-Dependent Association Between Breast Cancer and Risk of Ischemic Stroke: A Nationwide Cohort Study.

Neurology·2026
Same author

AI-Assisted Medical Documentation in a Multilingual Swiss Health Care System: Proof-of-Concept Study.

JMIR AI·2026
Same author

Compatibility of family life with an academic career in plastic surgery: A European comparison.

The surgeon : journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·2026
Same author

All-Cause Mortality and Secondary Malignancy in Patients with Pheochromocytoma/Paraganglioma.

Endocrinology and metabolism (Seoul, Korea)·2026

Related Experiment Video

Updated: Sep 16, 2025

Author Spotlight: Exploring the Potential of Fat-Derived Stromal Vascular Fraction for Wound Healing
05:30

Author Spotlight: Exploring the Potential of Fat-Derived Stromal Vascular Fraction for Wound Healing

Published on: November 17, 2023

715

Topical Application of SVF/PRF in Thermal Injuries-A Retrospective Analysis.

Lukas Naef1, Mauro Vasella1, Jennifer Watson1

  • 1Department of Plastic Surgery and Hand Surgery, University Hospital Zurich, 8091 Zurich, Switzerland.

Journal of Clinical Medicine
|July 12, 2025
PubMed
Summary

Topical stromal vascular fraction (SVF) and platelet-rich fibrin (PRF) show potential for treating burn wounds, but frequent residual defects limit their current use as a standard therapy.

Keywords:
PRFSVFburnstem cell

More Related Videos

Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases
07:36

Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases

Published on: July 3, 2025

209
Stromal Vascular Fraction-enriched Fat Grafting for the Treatment of Symptomatic End-neuromata
07:58

Stromal Vascular Fraction-enriched Fat Grafting for the Treatment of Symptomatic End-neuromata

Published on: November 23, 2017

7.8K

Related Experiment Videos

Last Updated: Sep 16, 2025

Author Spotlight: Exploring the Potential of Fat-Derived Stromal Vascular Fraction for Wound Healing
05:30

Author Spotlight: Exploring the Potential of Fat-Derived Stromal Vascular Fraction for Wound Healing

Published on: November 17, 2023

715
Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases
07:36

Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases

Published on: July 3, 2025

209
Stromal Vascular Fraction-enriched Fat Grafting for the Treatment of Symptomatic End-neuromata
07:58

Stromal Vascular Fraction-enriched Fat Grafting for the Treatment of Symptomatic End-neuromata

Published on: November 23, 2017

7.8K

Area of Science:

  • Regenerative Medicine
  • Burn Surgery
  • Wound Healing Research

Background:

  • Traditional burn wound management has limitations.
  • Stromal vascular fraction (SVF) and platelet-rich fibrin (PRF) are emerging regenerative therapies.
  • This study evaluates combined SVF and PRF for thermal injuries.

Purpose of the Study:

  • To assess the efficacy of combined topical SVF and PRF in treating deep partial-thickness and mixed-pattern burns.
  • To analyze healing outcomes, need for further surgery, and scar quality.
  • To identify potential benefits and limitations of this combined regenerative approach.

Main Methods:

  • Retrospective analysis of 13 patients with thermal injuries treated from 2018-2020.
  • Combined topical SVF and PRF applied after eschar debridement.
  • Evaluation of healing time, additional surgical interventions, and scar outcomes using the Manchester Scar Scale (MSS).

Main Results:

  • A mean of 6.3% of total body surface area was treated with SVF and PRF.
  • Five patients required additional surgery for residual defects.
  • Complete healing occurred within 20 days for uncomplicated cases and 51 days for those with defects; higher MSS scores correlated with additional surgery.
  • No adverse events were reported.

Conclusions:

  • Combined topical SVF and PRF may offer a less invasive treatment option for certain burn types.
  • Frequent residual defects and regulatory issues with SVF preclude its current use as a standard treatment.
  • Further research is needed to optimize this regenerative approach for burn wound management.