Dimethyl Isosorbide: An Innovative Bio-Renewable Solvent for Sustainable Chromatographic Applications.

Area of Science:

• Green Chemistry
• Analytical Chemistry
• Physical Chemistry

Background:

• Growing environmental concerns and regulations necessitate alternatives to toxic conventional solvents.
• Dimethyl isosorbide (DMI) is a bio-renewable solvent with potential to replace hazardous glycol ethers.
• The application of DMI as a solvent in liquid chromatography (LC) remains largely unexplored.

Purpose of the Study:

• To conduct a physicochemical characterization of DMI.
• To evaluate DMI's potential as an innovative solvent in LC analyses.
• To assess DMI's suitability as a sustainable alternative in pharmaceutical analysis.

Main Methods:

• Determined the partition coefficient (log P) using the OECD 107 method.
• Measured viscosity of DMI and its mixtures with water and ethanol at various temperatures (25°C, 40°C, 60°C).
• Employed a Central Composite Face 2^3 experimental design to study chromatographic behavior and optimize mobile phase composition.

Main Results:

• DMI exhibits a partition coefficient (log P) of -0.44.
• Viscosity measurements ranged from 1.28 mPa·s at 60°C to 2.62 mPa·s at 40°C.
• Optimized conditions showed 50% (v/v) DMI in mobile phases at 40°C column temperature, with backpressures of 160-300 bar and UV cut-off at 240 nm.

Conclusions:

• DMI is a viable and effective eluent in LC, suitable for pharmaceutical analysis.
• The study demonstrates DMI's potential as a sustainable, bio-renewable alternative to conventional organic solvents in LC.
• Utilizing DMI supports eco-friendly practices in analytical chemistry and pharmaceutical quality control.