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Hydrazides as Powerful Tools in Medicinal Chemistry: Synthesis, Reactivity, and Biological Applications
Sofia Teixeira1,2, Elisabete M S Castanheira2, M Alice Carvalho1
1Centre of Chemistry of University of Minho (CQ-UM), Campus de Gualtar, 4710-057 Braga, Portugal.
Molecules (Basel, Switzerland)
|July 12, 2025
Summary
Scientists are exploring novel hydrazide compounds to combat drug resistance and toxicity. This review details synthesis methods and biological applications of these promising drug candidates and their derivatives.
Area of Science:
- Medicinal Chemistry
- Organic Synthesis
- Pharmacology
Background:
- Growing drug resistance and toxicity of existing medications necessitate novel therapeutic agents.
- Hydrazides offer a versatile scaffold for developing diverse bioactive compounds.
- Recent advancements focus on hydrazide derivatives for various therapeutic applications.
Purpose of the Study:
- To review synthesis strategies for hydrazides and their derivatives.
- To summarize the biological activities of these compounds.
- To provide insights into reaction conditions and purification techniques.
Main Methods:
- Literature review of studies published in the last five years.
- Analysis of synthetic routes for hydrazides, hydrazide-hydrazones, and heterocyclic derivatives.
- Compilation of data on biological activities and experimental conditions.
Main Results:
- Identified various synthetic pathways for hydrazide derivatives.
- Documented a broad spectrum of biological activities, including antimicrobial and anticancer properties.
- Detailed experimental parameters and purification methods for synthesized compounds.
Conclusions:
- Hydrazides and their derivatives represent a valuable class of compounds for drug discovery.
- Further research into their synthesis and biological evaluation is warranted.
- This review serves as a resource for researchers in medicinal chemistry and drug development.
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