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Is There Any Correlation Between Green Synthesis Parameters and the Properties of Obtained Selenium Nanoparticles?
Aleksandra Sentkowska1, Julia Folcik2, Jakub Szmytke2
1Heavy Ion Laboratory, University of Warsaw, Pasteura 5A, 02-093 Warsaw, Poland.
Molecules (Basel, Switzerland)
|July 12, 2025
Summary
Green synthesis of selenium nanoparticles (SeNPs) using medicinal herbs offers high stability. Optimal SeNP size depends on reagent ratios and temperature, with a 1:1 ratio yielding the smallest particles.
Area of Science:
- Nanotechnology
- Materials Science
- Green Chemistry
Background:
- Selenium nanoparticles (SeNPs) possess significant potential for biomedical applications.
- Green synthesis methods for SeNPs are gaining prominence due to their environmental benefits.
- Understanding synthesis conditions is crucial for tailoring SeNP properties.
Purpose of the Study:
- To investigate the impact of green synthesis conditions on selenium nanoparticle properties.
- To explore the use of eight different medicinal herb extracts for SeNP synthesis.
- To correlate synthesis parameters (reagent ratio, temperature) with SeNP characteristics.
Main Methods:
- Green synthesis of SeNPs using extracts from eight medicinal herbs.
- Systematic variation of reagent ratios and reaction temperatures.
- Characterization of SeNPs using zeta potential measurements.
- Analysis of correlations between synthesis conditions and nanoparticle size.
Main Results:
- All synthesized SeNPs exhibited high stability, indicated by negative zeta potential values (-11.8 to -29.4 mV).
- The strongest correlation between SeNP size and reagent ratio was observed at elevated temperatures (R=0.914) compared to room temperature (R=0.681).
- The smallest SeNPs were consistently produced using a 1:1 reagent ratio across different conditions.
Conclusions:
- Green synthesis using medicinal herbs provides a viable route to stable selenium nanoparticles.
- Reagent ratio and temperature are critical factors influencing SeNP size during green synthesis.
- A 1:1 reagent ratio is optimal for achieving smaller selenium nanoparticles via this method.

