Melatonin/Chitosan Biomaterials for Wound Healing and Beyond: A Multifunctional Therapeutic Approach

Area of Science:

• Biomaterials Science
• Polymer Chemistry
• Pharmacology

Background:

• Chitosan, a biocompatible polymer, offers antioxidant, antimicrobial, and absorptive properties, with high modification potential.
• Melatonin, an indoleamine, possesses antioxidant, anti-apoptotic, and anti-inflammatory activities, impacting immunomodulation and mitochondrial function.
• Combined use of chitosan and melatonin is emerging in various therapeutic fields.

Purpose of the Study:

• To review recent advancements in the synergistic application of chitosan and melatonin.
• To highlight their combined efficacy in wound healing, anti-cancer therapies, and tissue engineering.
• To explore potential applications in cosmetology, aesthetic medicine, and veterinary practice.

Main Methods:

• Literature review of recent scientific publications.
• Analysis of studies focusing on chitosan-melatonin formulations.
• Synthesis of findings on synergistic effects and applications.

Main Results:

• Chitosan-melatonin combinations demonstrate significant synergistic effects.
• Key applications include enhanced wound healing, anti-cancer therapies, and tissue regeneration (skin, bone).
• Effective utilization in drug delivery systems and potential in cosmetic and veterinary fields.

Conclusions:

• The combination of chitosan and melatonin presents a promising synergistic approach for diverse therapeutic applications.
• Further research into these biomaterials can drive innovation in regenerative medicine and drug delivery.
• Expanded use in cosmetology, aesthetic medicine, and veterinary practice is anticipated.