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Pain and Sleep Biomarkers in Participants Undergoing Orthopedic Surgeries
Manish Bhomia1,2, Nicholas A Giordano3, Krista B Highland4
1Department of Pathology, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD 20814, USA.
International Journal of Molecular Sciences
|July 12, 2025
Summary
Inflammatory biomarkers in blood are linked to chronic pain before and after orthopedic surgery. However, these markers did not show a connection to sleep disturbances in service members.
Area of Science:
- Orthopedic Surgery
- Pain Management
- Sleep Science
Background:
- Chronic pain and poor sleep negatively impact post-surgical outcomes.
- The link between peripheral blood biomarkers, pain, and sleep after orthopedic surgery is understudied.
Purpose of the Study:
- To analyze the relationship between blood cytokines/chemokines and chronic pain/sleep outcomes in US service members undergoing orthopedic surgery.
Main Methods:
- Prospective observational study of 114 active-duty service members undergoing orthopedic surgery.
- Blood samples analyzed for cytokines and chemokines using multiplex immunoassays.
- Pre- and post-surgical pain and sleep data collected via surveys.
Main Results:
- Cytokine and chemokine levels correlated significantly with pre- and post-surgical pain scores.
- Increased post-surgical pain was associated with higher hepatocyte growth factor and lower interleukin-2 receptor levels.
- No significant correlations were found between blood biomarkers and sleep disturbance scores.
Conclusions:
- Peripheral blood inflammatory biomarkers are associated with pre- and post-surgical pain intensity.
- These biomarkers do not appear to be associated with sleep disturbances following orthopedic surgery.
