Tumor-Associated Macrophage in Breast Tumor Microenvironment

Area of Science:

• Oncology
• Immunology

Background:

• Breast cancer (BC) is a leading cause of cancer mortality globally.
• The breast tumor microenvironment (Br-TME) significantly impacts BC development and patient prognosis.
• Tumor-associated macrophages (TAMs) are key immune cells within the Br-TME, influencing critical processes like angiogenesis, immunosuppression, metastasis, and chemoresistance.

Purpose of the Study:

• To review the macrophage niche within the Br-TME, focusing on TAM origins.
• To summarize molecular mechanisms of TAM interactions with other Br-TME components.
• To provide an overview of TAM-targeting drugs and drug delivery technologies for BC treatment.

Main Methods:

• Literature review of TAMs in the breast tumor microenvironment.
• Analysis of molecular pathways and interactions involving TAMs.
• Survey of current and emerging therapeutic strategies targeting TAMs in breast cancer.

Main Results:

• TAMs play multifaceted roles in promoting BC progression, including fostering tumor growth and spread.
• Understanding TAM origins and functions is crucial for developing effective therapies.
• Various drugs and advanced drug delivery systems are being investigated to target TAMs in BC.

Conclusions:

• Targeting TAMs holds significant potential for improving breast cancer treatment outcomes.
• Further research into TAM dynamics can identify critical pathways for therapeutic intervention.
• This review provides a foundation for future clinical trials aimed at leveraging TAM-targeting strategies for BC patients.