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Association of Tissue Expression of LAG-3 and TIM-3 with Clinical Features in Ovarian Cancer

  • 0Department of Reconstructive Surgery and Gynecological Oncology, Pomeranian Medical University, Al. Powstańców Wielkopolskich 72, 70-111 Szczecin, Poland.
International Journal of Molecular Sciences +

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July 12, 2025

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July 12, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

This study investigated Lymphocyte-activation gene 3 (LAG-3) and T-cell immunoglobulin and mucin-domain containing-3 (TIM-3) protein expression in ovarian cancer. Findings suggest LAG-3 and TIM-3 may serve as potential biomarkers for clinical indicators in ovarian cancer patients.

Area Of Science

  • Oncology
  • Immunology
  • Biomarker Discovery

Background

  • Ovarian cancer is a leading cancer in women, necessitating ongoing research for effective biomarkers.
  • Identifying novel protein markers can aid in understanding disease progression and clinical characteristics.

Purpose Of The Study

  • To evaluate the expression of LAG-3 and TIM-3 proteins in ovarian cancer tissues.
  • To explore the association of LAG-3 and TIM-3 expression with clinical signs in ovarian cancer patients.

Main Methods

  • Immunohistochemistry was used to assess LAG-3 and TIM-3 protein expression in 58 ovarian cancer tissue samples.
  • Patients were categorized into high-grade serous ovarian cancer (HGSOC) and non-HGSOC groups.
  • Statistical analysis was performed using StatView 5.0 software.

Main Results

  • LAG-3 and TIM-3 proteins predominantly exhibited positive, moderate, or strong expression.
  • LAG-3 expression correlated with Body Mass Index (BMI) in the non-HGSOC group.
  • TIM-3 expression was associated with age in the overall ovarian cancer cohort.
  • A significant association was observed between LAG-3 and TIM-3 expression across all patient groups.

Conclusions

  • LAG-3 and TIM-3 proteins show significant expression in ovarian cancer tissues.
  • These proteins may serve as potential biomarkers for specific clinical features like BMI and age.
  • Co-expression of LAG-3 and TIM-3 suggests a potential interplay in ovarian cancer pathogenesis.

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