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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
283
Obesity-Related Glomerulosclerosis-How Adiposity Damages the Kidneys
Justyna Zbrzeźniak-Suszczewicz1, Agata Winiarska1, Agnieszka Perkowska-Ptasińska2
1Department of Nephrology, Hypertension and Internal Medicine, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland.
International Journal of Molecular Sciences
|July 12, 2025
Summary
Obesity significantly harms kidneys through inflammation and compression, often worsening existing chronic kidney disease (CKD). GLP1 receptor agonists show promise in preventing kidney injury in obese individuals.
Area of Science:
- Nephrology
- Endocrinology
- Cardiovascular Medicine
Background:
- Obesity, hypertension, and type 2 diabetes form a triad linked to increased cardiovascular morbidity and mortality.
- Chronic kidney disease (CKD) is a major global health threat, often exacerbated by these conditions.
- The kidney is a primary target organ for obesity-related damage.
Purpose of the Study:
- To review the mechanisms by which obesity causes kidney injury.
- To discuss the role of adipose tissue in renal dysfunction.
- To explore potential therapeutic strategies for obesity-related kidney disease.
Main Methods:
- Review of existing literature on obesity and kidney disease.
- Analysis of pathophysiological pathways linking obesity to renal damage.
- Evaluation of current and emerging treatment options.
Main Results:
- Obesity-related glomerulosclerosis (ORG) is a distinct pattern of renal injury.
- Adipose tissue releases inflammatory cytokines and growth factors, damaging kidney cells.
- Perirenal adipose tissue (PRAT) can compress renal parenchyma and vessels.
- Kidneys in obese individuals exhibit increased sodium reabsorption, leading to intraglomerular hypertension and hyperfiltration.
- Lifestyle interventions, bariatric surgery, and pharmacological agents show potential benefits.
- GLP1 receptor agonists, including semaglutide and tirzepatide, are identified as promising treatments.
Conclusions:
- Obesity-related disorders significantly contribute to kidney injury and CKD progression.
- Targeting adipose tissue and its mediators is crucial for kidney protection.
- GLP1 receptor agonists represent a promising therapeutic avenue for preventing kidney damage in obesity.
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