Related Experiment Video
Updated: Sep 16, 2025
11:56
In Vitro Bioluminescence Assay to Characterize Circadian Rhythm in Mammary Epithelial Cells
Published on: September 28, 2017
9.9K
Tick-Tock: Cancer Cell Division Cycle Clocks Strike Midnight
Scott C Schuyler1,2, Hsin-Yu Chen1, Tran Thi Bao Nguyen1
1Department of Biomedical Sciences, College of Medicine, Chang Gung University, Kwei-Shan, Taoyuan 333, Taiwan.
International Journal of Molecular Sciences
|July 12, 2025
Summary
Aneuploid cancer cells may be more vulnerable to forced overgrowth than healthy cells. This study proposes targeting the anaphase-promoting complex/cyclosome (APC/C) to induce overgrowth and test this hypothesis in cancer therapy.
Area of Science:
- Cell Biology
- Cancer Biology
- Molecular Biology
Background:
- Eukaryotic cells maintain uniform size through coordinated mass doubling and division.
- Cancer cells, often aneuploid, experience proteotoxic stress and altered unfolded-protein response.
- Heat-shock proteins (HSPs) are crucial for managing protein folding under stress.
Purpose of the Study:
- To hypothesize that aneuploid cancer cells are more sensitive to forced overgrowth than diploid cells.
- To explore targeting the anaphase-promoting complex/cyclosome (APC/C) to induce forced overgrowth in cancer cells.
- To propose novel combination therapies for cancer treatment.
Main Methods:
- Hypothesizing differential sensitivity to forced overgrowth based on ploidy.
- Suggesting modulation of the anaphase-promoting complex/cyclosome (APC/C) activity.
- Proposing experimental combinations of APC/C inhibitors with HSP90 inhibitors.
Main Results:
- Forced overgrowth increases protein production and the window for protein misfolding/aggregation.
- Cancer cells' proteotoxic stress may exacerbate negative effects of forced overgrowth.
- APC/C inhibition is proposed as a strategy to induce forced overgrowth.
Conclusions:
- Aneuploid cancer cells might be uniquely susceptible to forced overgrowth.
- Targeting APC/C activity offers a potential therapeutic strategy.
- Investigating combinations of APC/C and HSP90 inhibitors may yield new cancer treatments.
Keywords:
anaphase-promoting complex/cyclosome (APC/C)cancercell division cycleheat-shock protein 90 (HSP90)proteotoxic stressMore Related Videos
Related Concept Videos
00:56What is the Cell Cycle?
7.3K
The cell cycle refers to the sequence of events occurring throughout a typical cell’s life. In eukaryotic cells, the somatic cell cycle has two stages: the interphase and the mitotic phase. During interphase, the cell grows, performs its basic metabolic functions, copies its DNA, and prepares for mitotic cell division. Then, during mitosis and cytokinesis, the cell divides its nuclear and cytoplasmic materials, respectively. This generates two daughter cells that are identical to the...
7.3K
02:19Circadian Rhythms and Gene Regulation
4.2K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.2K
01:27Molecular Factors Affecting Cell Division
3.3K
Several external and internal factors influence the initiation and inhibition of cell division. For instance, the death of nearby cells or the release of human growth hormone (hGH) promotes cell division. In contrast, lack of hGH or crowding of cells can inhibit cell division.
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
Several proteins function as internal regulators to ensure each cell cycle stage is completed faithfully before proceeding to the next. Regulator molecules may act directly or influence the activity or production of other...
3.3K
02:12What is Cancer?
11.2K
Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of...
11.2K
02:39Positive Regulator Molecules
5.7K
Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
5.7K
01:28The Cell Cycle Control System
3.5K
The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and...
3.5K