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An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
Published on: July 31, 2019
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Using Gut Microbiota Modulation as a Precision Strategy Against Obesity
Kwang-Rim Baek1, Saloni Singh1, Hye-Seon Hwang1
1Department of Food Science and Biotechnology, Seoul National University of Science and Technology, Seoul 01811, Republic of Korea.
International Journal of Molecular Sciences
|July 12, 2025
Summary
The gut microbiome significantly impacts obesity development. Modulating gut bacteria with probiotics and prebiotics offers a novel strategy for obesity prevention and treatment.
Area of Science:
- Microbiology
- Metabolic Disorders
- Human Health
Background:
- Obesity is a global health crisis with complex origins.
- Emerging research implicates the gut microbiota in metabolic regulation and obesity.
- Understanding these microbial interactions is key to developing new therapies.
Purpose of the Study:
- To review the intricate relationship between gut microbiota composition and obesity.
- To elucidate the mechanisms by which microbial communities influence host metabolism and energy balance.
- To explore microbiota-targeted interventions for obesity management.
Main Methods:
- Comprehensive literature review of studies on gut microbiota and obesity.
- Analysis of microbial taxa, their metabolites (e.g., short-chain fatty acids), and host signaling pathways.
- Evaluation of precision strategies for gut microbiome modulation.
Main Results:
- Alterations in gut microbiota composition are linked to obesity.
- Microbial metabolites and their interactions with host pathways significantly affect energy homeostasis.
- Specific microbial profiles are associated with metabolic dysfunction.
Conclusions:
- The gut microbiome plays a critical role in the pathogenesis of obesity.
- Targeted modulation of the gut microbiota, including probiotics and prebiotics, presents a promising therapeutic avenue.
- Further research into microbiota engineering could lead to innovative obesity treatments.
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