FcRL1, a New B-Cell-Activating Co-Receptor
Zhitao Chen1, Chenxi Miao1, Yan Zhang2
1Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100083, China.
Abstract:
Fc receptor-like 1 (FcRL1), a co-receptor specifically expressed on the surface of B-cells, plays a pivotal role in modulating B-cell immune activation and orchestrating humoral immune responses. This comprehensive review systematically synthesizes research advances in FcRL1 mediated transmembrane signal transduction mechanisms, its regulatory capacity in humoral immune responses, expression patterns during B-cell differentiation and development, and expression dynamics in B-cell malignancies, while critically evaluating the therapeutic potential of FcRL1 as a cellular targeting candidate.
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