Development of a γ-Cyclodextrin-Based Cryogel Loaded with Trimethoprim for Acne Treatment: Design, Synthesis, and In...

Area of Science:

• Materials Science
• Pharmaceutical Sciences
• Biotechnology

Background:

• Host-guest complexes within cryogels show potential for topical drug delivery.
• Enhancing drug solubility and stability is crucial for effective topical formulations.
• Acne treatment requires localized and sustained delivery of antibacterial agents.

Purpose of the Study:

• To design and develop a cryogel-based patch for acne treatment.
• To create a hybrid system integrating a trimethoprim (TMP) and gamma-cyclodextrin (γ-CD) inclusion complex.
• To evaluate the sustained release, antibacterial efficacy, and biocompatibility of the developed patch.

Main Methods:

• Synthesis of the γ-CD and TMP inclusion complex using mortar-assisted kneading.
• Cryogel formulation via radical cryopolymerization of the complex with [2-(acryloyloxy)ethyl]trimethylammonium chloride (AETMA).
• Characterization using FT-IR, TGA, and SEM; in vitro release studies; antibacterial assays; and cytocompatibility tests.

Main Results:

• The cryogel system demonstrated sustained release of TMP, following the Korsmeyer-Peppas diffusion model.
• Effective antibacterial activity against Staphylococcus aureus was confirmed.
• The formulation exhibited good cytocompatibility, indicating suitability for topical application.

Conclusions:

• The developed cryogel patch effectively delivers TMP for sustained acne treatment.
• The hybrid material leverages γ-CD for drug reservoir function and AETMA for skin adhesion.
• This innovative material holds significant promise for localized and prolonged topical acne therapy.