Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Apoptosis01:30

Apoptosis

12.0K
Apoptosis is a combination of two Greek words, 'apo' and 'ptosis,' meaning separation and falling off, respectively. Hippocrates used this word to describe gangrene, which was caused due to bandaging of fractured bones. Apoptosis was distinguished from necrosis in 1970 when John Kerr reported observations of morphological changes occurring during apoptosis. During one experiment, he observed that the disruption of blood supply to the liver tissue resulted in a size...
12.0K
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

65
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
65
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

37
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
37
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

24
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
24
Overview of Cell Death01:30

Overview of Cell Death

7.8K
Cell death is an essential process where the body gets rid of old or damaged cells. Cell proliferation and death need to be balanced, as an imbalance between the two may lead to cancer or autoimmune diseases.
Cell death was observed in the early 19th century, but there was no experimental evidence to prove it. In 1842, Carl Vogt first discovered cell death in a metamorphic toad; however, it was not termed ‘cell death.’ Scientists discovered different cell death pathways only in the...
7.8K
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

1.9K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of gastrectomy on the risk of alcohol-associated liver disease in patients with gastric cancer.

Scientific reports·2026
Same author

A nomogram for assessing the risk of MAFLD based on the albumin-to-gamma-glutamyl transferase ratio.

European journal of medical research·2025
Same author

A columnar graphical prediction model for hepatic encephalopathy secondary to decompensated cirrhosis in hepatitis B cirrhosis.

BMC infectious diseases·2025
Same author

Clinical Characteristics and Prognosis of Esophageal Squamous Cell Carcinoma in Patients Under 60 Years of Age.

Cancers·2025
Same author

Clinical outcomes of underwater endoscopic mucosal resection for esophageal subepithelial tumors.

Medicine·2025
Same author

Epidemiology of Chronic Hepatitis C in First Nations Populations in Canadian Prairie Provinces.

Pathogens (Basel, Switzerland)·2025

Related Experiment Video

Updated: Sep 16, 2025

Isolation and Physiological Analysis of Mouse Cardiomyocytes
11:02

Isolation and Physiological Analysis of Mouse Cardiomyocytes

Published on: September 7, 2014

23.3K

Apoptosis in Cardiac Conditions Including Cirrhotic Cardiomyopathy.

Fengxue Yu1,2, Dae Gon Ryu1,3, Ki Tae Yoon1,3

  • 1Liver Unit, University of Calgary Cumming School of Medicine, Calgary, AB T2N 2T8, Canada.

International Journal of Molecular Sciences
|July 12, 2025
PubMed
Summary

Apoptosis, or programmed cell death, contributes to cardiovascular diseases like heart failure. Targeting apoptosis offers a potential treatment strategy for conditions such as cirrhotic cardiomyopathy, where current therapies are ineffective.

Keywords:
apoptosiscirrhosiscirrhotic cardiomyopathyheart diseasestreatment

More Related Videos

Detecting Anastasis In Vivo by CaspaseTracker Biosensor
20:16

Detecting Anastasis In Vivo by CaspaseTracker Biosensor

Published on: February 1, 2018

9.4K
Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples
14:39

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples

Published on: April 21, 2014

17.5K

Related Experiment Videos

Last Updated: Sep 16, 2025

Isolation and Physiological Analysis of Mouse Cardiomyocytes
11:02

Isolation and Physiological Analysis of Mouse Cardiomyocytes

Published on: September 7, 2014

23.3K
Detecting Anastasis In Vivo by CaspaseTracker Biosensor
20:16

Detecting Anastasis In Vivo by CaspaseTracker Biosensor

Published on: February 1, 2018

9.4K
Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples
14:39

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples

Published on: April 21, 2014

17.5K

Area of Science:

  • Cardiovascular Biology
  • Cell Death Mechanisms
  • Pathophysiology

Background:

  • Apoptosis (programmed cell death) is a critical process in cardiovascular diseases.
  • The heart is particularly vulnerable to apoptosis due to high mitochondrial content in cardiomyocytes.
  • Excessive apoptosis contributes to cardiac dysfunction in heart failure, ischemic heart disease, and cirrhotic cardiomyopathy.

Purpose of the Study:

  • To review the mechanisms of apoptosis in various cardiac conditions.
  • To explore potential anti-apoptotic therapies for cardiovascular diseases, including cirrhotic cardiomyopathy.
  • To highlight the unmet need for effective treatments for cirrhotic cardiomyopathy.

Main Methods:

  • Literature review of apoptotic pathways (intrinsic and extrinsic).
  • Analysis of apoptosis's role in cardiac pathophysiology.
  • Survey of current and potential therapeutic strategies targeting apoptosis.

Main Results:

  • Apoptosis, via intrinsic and extrinsic pathways, is implicated in cardiac dysfunction.
  • Cirrhotic cardiomyopathy presents a unique challenge with no effective current treatments.
  • Anti-apoptotic strategies show promise for preventing or mitigating cardiac disease progression.

Conclusions:

  • Apoptosis is a key pathogenic factor in cardiovascular diseases.
  • Targeting apoptosis represents a promising therapeutic avenue for cardiac conditions, especially cirrhotic cardiomyopathy.
  • Further research into anti-apoptotic therapies is crucial for managing heart diseases.