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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Related Experiment Video

Updated: Sep 16, 2025

A Novel in vivo Gene Transfer Technique and in vitro Cell Based Assays for the Study of Bone Loss in Musculoskeletal Disorders
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Inflammaging-Driven Osteoporosis: Is a Galectin-Targeted Approach Needed?

Marina Russo1,2, Caterina Claudia Lepre3,4, Annalisa Itro5

  • 1PhD Course in National Interest in Public Administration and Innovation for Disability and Social Inclusion, Department of Mental, Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", 80138 Naples, Italy.

International Journal of Molecular Sciences
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PubMed
Summary

Osteoporosis involves bone fragility and fractures. This review explores Galectins (Gals), proteins involved in inflammation and aging, as potential therapeutic targets for osteoporosis treatment.

Keywords:
Galectin-1 (Gal-1)Galectin-3 (Gal-3)Galectins (Gals)osteoporosisosteoporotic fractures

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Area of Science:

  • Biochemistry
  • Immunology
  • Gerontology

Background:

  • Osteoporosis (OP) is a chronic condition marked by decreased bone mass and microarchitectural changes, increasing fracture risk.
  • High morbidity, disability, and healthcare expenses associated with OP necessitate novel biomarkers and treatments.
  • Inflammation and aging are key contributors to bone fragility in osteoporosis.

Purpose of the Study:

  • To review the role of Galectins (Gals) in inflammation and aging processes related to bone fragility.
  • To explore Galectins as potential therapeutic targets for osteoporosis.

Main Methods:

  • This study is a narrative review.
  • It synthesizes existing literature on Galectins, inflammation, aging, and osteoporosis.
  • The review focuses on the biological mechanisms linking these factors.

Main Results:

  • Galectins (Gals) are implicated in the complex interplay of inflammation and aging that exacerbates bone fragility.
  • Evidence suggests Galectins influence cellular processes critical to bone metabolism and immune response.
  • The review highlights specific Galectins and their pathways relevant to OP pathogenesis.

Conclusions:

  • Galectins represent a promising area for novel therapeutic strategies in osteoporosis.
  • Targeting Galectins could offer a new approach to managing bone fragility by addressing underlying inflammatory and aging mechanisms.
  • Further research into Galectin-mediated pathways is warranted for effective OP treatment development.