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Collagen-Based Drug Delivery Agents for Glioblastoma Multiforme Treatment
Barbara Guzdek1,2, Kaja Fołta1,2, Natalia Staniek1,2
1Department of Physical Chemistry and Technology of Polymers, Silesian University of Technology, M. Strzody 9, 44-100 Gliwice, Poland.
International Journal of Molecular Sciences
|July 12, 2025
Summary
Collagen shows promise as a biocompatible drug carrier for glioblastoma multiforme (GBM) treatment. This advanced approach enables localized chemotherapy delivery, potentially improving patient outcomes for this aggressive brain tumor.
Area of Science:
- Biomaterials Science
- Oncology
- Neuroscience
Background:
- Glioblastoma multiforme (GBM) is an aggressive brain tumor with poor prognosis.
- Conventional treatments (surgery, radiotherapy, chemotherapy) have limited efficacy due to tumor invasiveness and the blood-brain barrier.
- Localized adjuvant chemotherapy is crucial for improving GBM patient outcomes.
Purpose of the Study:
- To review recent applications of collagen as a drug delivery system for GBM.
- To highlight collagen's potential for extended chemotherapeutic agent delivery directly to GBM sites.
- To explore future opportunities for collagen-based GBM therapies.
Main Methods:
- Literature review of studies utilizing collagen for localized chemotherapy in GBM.
- Analysis of collagen's properties relevant to drug delivery in the central nervous system.
- Evaluation of collagen's biocompatibility, biodegradability, and safety profile.
Main Results:
- Collagen demonstrates excellent biocompatibility, biodegradability, and low antigenicity.
- Its native presence in the central nervous system extracellular matrix enhances its suitability.
- Collagen facilitates extended, localized delivery of chemotherapeutic agents to the GBM site.
Conclusions:
- Collagen is a promising biomaterial for regional chemotherapy in GBM.
- It offers a safe and effective platform for localized drug delivery, overcoming blood-brain barrier challenges.
- Further research into collagen-based drug carriers could significantly advance GBM treatment strategies.
