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Impact of Aerobic Training on Transcriptomic Changes in Skeletal Muscle of Rats with Cardiac Cachexia
Daniela Sayuri Inoue1, Quinten W Pigg1, Dillon R Harris1
1Department of Kinesiology and Sport Management, Texas A&M University, College Station, TX 77845, USA.
Aerobic training helps cardiac cachexia (CC) by altering skeletal muscle gene expression. This study found exercise reduced altered lipid metabolism genes in rats with heart failure-induced CC.
Area of Science:
- Cardiology
- Molecular Biology
- Exercise Physiology
Background:
- Cardiac cachexia (CC) is a severe manifestation of heart failure (HF), involving skeletal muscle wasting.
- The molecular mechanisms by which exercise impacts CC remain unclear.
- Understanding these mechanisms can reveal therapeutic targets for CC.
Purpose of the Study:
- To investigate the effects of aerobic training on gene expression in skeletal muscle of rats with CC.
- To identify molecular pathways affected by exercise in CC.
- To explore the therapeutic potential of aerobic training in CC.
Main Methods:
- Heart failure was induced in Wistar rats using monocrotaline.
- Aerobic training involved treadmill running for 4 weeks.
- RNA sequencing (RNA-seq) analyzed gene expression in the medial gastrocnemius muscle.
Main Results:
- Sedentary cachectic rats showed 114 differentially expressed genes (DEGs), while exercised rats had only 18 DEGs.
- Analysis revealed disrupted lipid metabolism in sedentary cachectic rats, which was normalized by exercise.
- Aerobic training modulated the expression of the Dgat2 gene, linked to lipid metabolism.
Conclusions:
- Aerobic training significantly reduces the number of altered genes in skeletal muscle of rats with CC.
- Exercise appears to mitigate CC-related transcriptional changes in lipid metabolism.
- Aerobic training demonstrates therapeutic potential for managing cardiac cachexia.
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