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The Trajectories of Neuromuscular Aging (TRAJECTOR-AGE Clinical Trial): Study Rationale and Methodological Protocol

  • 0Geriatric Clinic Unit, Medical Geriatric Rehabilitative Department, University Hospital of Parma, Parma, Italy.
Journal of the American Geriatrics Society +

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July 12, 2025

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July 12, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

This study tracks neuromuscular decline in aging adults over two years, identifying biomarkers to help maintain function and independence. It aims to understand aging mechanisms and inform interventions for healthier aging.

Area Of Science

  • Gerontology and aging research
  • Neuromuscular physiology
  • Biomarker discovery

Background

  • Aging is associated with progressive neuromuscular decline, impacting function and independence.
  • Understanding the trajectories and mechanisms of this decline is crucial for developing effective interventions.

Purpose Of The Study

  • To examine the structural, metabolic, and functional changes in neuromuscular aging.
  • To identify early biomarkers and key mechanisms driving neuromuscular decline.
  • To guide interventions aimed at preserving function and independence in older adults.

Main Methods

  • Prospective, longitudinal cohort study (TRAJECTOR-AGE) over 2 years in Italy.
  • Recruitment of healthy middle-aged and older adults, excluding those with significant comorbidities.
  • Comprehensive assessments including clinical evaluations, physiological tests, imaging (ultrasound, MRI), and biological sample collection for biomarker analysis.

Main Results

  • Integration of longitudinal clinical, functional, and molecular data.
  • Clarification of pathophysiological mechanisms underlying age-related neuromuscular decline.
  • Assessment of inter-individual variability and the role of physical activity in aging trajectories.

Conclusions

  • A multidimensional approach can identify individuals at risk for functional decline.
  • Findings will inform the development of targeted interventions for healthy aging.
  • Early identification and intervention can promote independence and improve quality of life in aging populations.

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