The Trajectories of Neuromuscular Aging (TRAJECTOR-AGE Clinical Trial): Study Rationale and Methodological Protocol

Area of Science:

• Gerontology and aging research
• Neuromuscular physiology
• Biomarker discovery

Background:

• Aging is associated with progressive neuromuscular decline, impacting function and independence.
• Understanding the trajectories and mechanisms of this decline is crucial for developing effective interventions.

Purpose of the Study:

• To examine the structural, metabolic, and functional changes in neuromuscular aging.
• To identify early biomarkers and key mechanisms driving neuromuscular decline.
• To guide interventions aimed at preserving function and independence in older adults.

Main Methods:

• Prospective, longitudinal cohort study (TRAJECTOR-AGE) over 2 years in Italy.
• Recruitment of healthy middle-aged and older adults, excluding those with significant comorbidities.
• Comprehensive assessments including clinical evaluations, physiological tests, imaging (ultrasound, MRI), and biological sample collection for biomarker analysis.

Main Results:

• Integration of longitudinal clinical, functional, and molecular data.
• Clarification of pathophysiological mechanisms underlying age-related neuromuscular decline.
• Assessment of inter-individual variability and the role of physical activity in aging trajectories.

Conclusions:

• A multidimensional approach can identify individuals at risk for functional decline.
• Findings will inform the development of targeted interventions for healthy aging.
• Early identification and intervention can promote independence and improve quality of life in aging populations.