Related Experiment Video
Updated: Sep 16, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
Extracellular vesicles in pregnancy-related disorders: from mechanisms to clinical implications
Xiaojing He1, Shiqi Liu1, Yudi Wang1
1Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
Abstract:
The discovery of extracellular vesicles (EVs), including exosomes, microvesicles, and shedding vesicles, signifies a paradigm shift in our understanding of cellular communication and a variety of biological processes, encompassing immune regulation, disease pathogenesis, and tissue repair. Particularly in the realm of pregnancy-related diseases, EVs have unveiled new perspectives and tools for deciphering the molecular mechanisms underlying pregnancy and its associated disorders. Emerging evidence indicates the multifaceted role of EVs in placental formation, regulation of maternal-fetal immune balance, and the development of pregnancy complications. The review aims to synthesize current research findings on the potential applications of EVs in pregnancy diseases and may help identify the EVs as diagnostic or therapeutic strategies for pregnancy-related disorders.
Related Concept Videos
Overview of Exosomes
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Intralumenal Vesicles and Multivesicular Bodies
Overview of Secretory Vesicles
Various proteins regulate the aggregation of molecules inside the secretory vesicles. Chromogranins...
Teratogenicity

