Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

6.2K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
6.2K
Conservative Site-specific Recombination and Phase Variation02:53

Conservative Site-specific Recombination and Phase Variation

6.1K
Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
The recognition sites for Cre recombinase called LoxP...
6.1K
Crossing Over01:30

Crossing Over

4.8K
Crossing over is the exchange of genetic information between homologous chromosomes during prophase I of meiosis I. Genetic recombination gives rise to allelic diversity in the newly formed daughter cells. In humans, crossing over produces genetically distinct haploid egg and sperm cells that undergo fertilization to produce unique offspring. Before cell division starts, the germ cell’s chromosome(s) undergo duplication in the S phase of the cell cycle. As the cells enter prophase I,...
4.8K
Homologous Recombination02:31

Homologous Recombination

4.9K
4.9K
Genetic Screens02:46

Genetic Screens

5.1K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.1K
Genetics of Speciation02:16

Genetics of Speciation

19.6K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
19.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Genetic prediction with ARG-powered linear algebra.

Genetics·2026
Same author

Tracing the evolutionary histories of ultra-rare variants using variational dating of large ancestral recombination graphs.

bioRxiv : the preprint server for biology·2026
Same author

Combined clinical, metabolomic, and polygenic scores for cardiovascular risk prediction.

European heart journal·2025
Same author

Soft 3D electromagnetic structures with rapid, complex shape morphing.

Science advances·2025
Same author

A Pandemic-Scale Ancestral Recombination Graph for SARS-CoV-2.

bioRxiv : the preprint server for biology·2025
Same author

On ARGs, pedigrees, and genetic relatedness matrices.

Genetics·2025

Related Experiment Video

Updated: Sep 16, 2025

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.3K

Tsbrowse: an interactive browser for ancestral recombination graphs.

Savita Karthikeyan1, Ben Jeffery1, Duncan Mbuli-Robertson1

  • 1Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford OX3 7LF, United Kingdom.

Bioinformatics (Oxford, England)
|July 12, 2025
PubMed
Summary
This summary is machine-generated.

Ancestral recombination graphs (ARGs) visualize genetic ancestry. A new Python tool, tsbrowse, offers interactive visualization for these complex evolutionary histories, aiding genetic data analysis.

More Related Videos

A Practical Guide to Phylogenetics for Nonexperts
12:00

A Practical Guide to Phylogenetics for Nonexperts

Published on: February 5, 2014

35.5K
Genome-wide Snapshot of Chromatin Regulators and States in Xenopus Embryos by ChIP-Seq
10:23

Genome-wide Snapshot of Chromatin Regulators and States in Xenopus Embryos by ChIP-Seq

Published on: February 26, 2015

12.6K

Related Experiment Videos

Last Updated: Sep 16, 2025

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
08:03

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

2.3K
A Practical Guide to Phylogenetics for Nonexperts
12:00

A Practical Guide to Phylogenetics for Nonexperts

Published on: February 5, 2014

35.5K
Genome-wide Snapshot of Chromatin Regulators and States in Xenopus Embryos by ChIP-Seq
10:23

Genome-wide Snapshot of Chromatin Regulators and States in Xenopus Embryos by ChIP-Seq

Published on: February 26, 2015

12.6K

Area of Science:

  • Population Genetics
  • Computational Biology
  • Bioinformatics

Background:

  • Ancestral recombination graphs (ARGs) model the evolutionary history of recombining sequences.
  • ARGs are crucial for population and statistical genetics, with increasing use in large-scale genetic data analysis.
  • Current limitations include a lack of effective visualization tools for ARG inference.

Purpose of the Study:

  • To introduce tsbrowse, an open-source, web-based Python application.
  • To provide interactive visualization of fundamental ARG components: nodes, edges, and mutations.
  • To facilitate hypothesis generation and validation in genetic ancestry studies.

Main Methods:

  • Development of a Python application, tsbrowse, for ARG visualization.
  • Implementation of interactive features for exploring genomic data.
  • Demonstration of scalability for large sample sizes.

Main Results:

  • tsbrowse enables interactive visualization of ARGs.
  • The tool supports various data sources and scenarios.
  • Key features include genomic browsability, user interactivity, and scalability.

Conclusions:

  • tsbrowse addresses the need for effective ARG visualization tools.
  • The application enhances the utility of ARG-based approaches in genetic research.
  • It supports validation and hypothesis generation in population genetics studies.