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Updated: Sep 16, 2025

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
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Developing stem cells for corneal disease: recent developments and future perspectives

Ansu Ann John1, Hooman Ahmadzadeh1, Alfonso L Sabater1

  • 1Corneal Innovation Laboratory, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.

Regenerative Medicine
|July 12, 2025
PubMed

Insights

Stem cell therapies offer new hope for vision restoration and corneal repair, addressing donor shortages. Continued research is vital for safety, efficacy, and accessibility of these advanced regenerative treatments.

Area of Science:

  • Ocular medicine
  • Regenerative medicine
  • Biotechnology

Background:

  • Stem cell therapies are transforming eye care, aiming to restore vision and repair corneal damage.
  • Advancements are driven by the need to address corneal donor scarcity and transplantation issues.

Purpose of the Study:

  • To review clinical trials and regulatory approvals for stem cell-based ocular therapies over the last seven years.
  • To categorize these advancements by target disease and assess overall progress.

Main Methods:

  • Comprehensive literature review of clinical trials and regulatory data.
  • Categorization of studies based on specific ocular diseases treated.
  • Analysis of safety, efficacy, and economic factors.

Main Results:

  • Significant progress in stem cell applications for ocular conditions has been observed.
  • The review covers advancements across various target diseases within the last seven years.

Conclusions:

  • Stem cell therapies show great promise but face challenges in safety, efficacy, and cost-effectiveness.
  • Future directions include gene editing, personalized medicine, and integrated approaches for improved outcomes.
Keywords:
Adult corneal stem cell nichecell therapycorneaeyeiPSCregenerative medicinetransplantation

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