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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration
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Developing stem cells for corneal disease: recent developments and future perspectives.

Ansu Ann John1, Hooman Ahmadzadeh1, Alfonso L Sabater1

  • 1Corneal Innovation Laboratory, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida, USA.

Regenerative Medicine
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Summary
This summary is machine-generated.

Stem cell therapies offer new hope for vision restoration and corneal repair, addressing donor shortages. Continued research is vital for safety, efficacy, and accessibility of these advanced regenerative treatments.

Keywords:
Adult corneal stem cell nichecell therapycorneaeyeiPSCregenerative medicinetransplantation

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Area of Science:

  • Ocular medicine
  • Regenerative medicine
  • Biotechnology

Background:

  • Stem cell therapies are transforming eye care, aiming to restore vision and repair corneal damage.
  • Advancements are driven by the need to address corneal donor scarcity and transplantation issues.

Purpose of the Study:

  • To review clinical trials and regulatory approvals for stem cell-based ocular therapies over the last seven years.
  • To categorize these advancements by target disease and assess overall progress.

Main Methods:

  • Comprehensive literature review of clinical trials and regulatory data.
  • Categorization of studies based on specific ocular diseases treated.
  • Analysis of safety, efficacy, and economic factors.

Main Results:

  • Significant progress in stem cell applications for ocular conditions has been observed.
  • The review covers advancements across various target diseases within the last seven years.

Conclusions:

  • Stem cell therapies show great promise but face challenges in safety, efficacy, and cost-effectiveness.
  • Future directions include gene editing, personalized medicine, and integrated approaches for improved outcomes.