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Published on: October 16, 2013
Scoring indices for assessing endoscopic disease activity in acute severe ulcerative colitis: a systematic review
Hadar Meringer1, Maia Kayal2, Vipul Jairath3,4,5,6
1Department of Gastroenterology, Meir Medical Center affiliated with the Gray Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel.
Background And Aims:
Endoscopy is important for assessing disease severity and potentially predicting treatment response in acute severe ulcerative colitis (ASUC). We aimed to identify and determine the operating properties of existing endoscopic indices/items used to assess disease activity in ASUC.
Methods:
MEDLINE, Embase, and Cochrane CENTRAL were searched from database inception to April 17, 2024 to identify individual items and scoring indices used to evaluate endoscopic disease activity in patients with ASUC. Subsequently, we performed another comprehensive search from database inception to July 29, 2024 to identify studies that assessed the validity, reliability, feasibility, and responsiveness of the identified items and scoring indices.
Results:
We identified 18 studies that reported endoscopic measures in patients with ASUC, including Endoscopic Activity Index, Mayo endoscopic subscore (MES), Severe Endoscopic Lesions, Ulcerative Colitis Endoscopic Index of Severity (UCEIS), and the Degree of Ulcerative Colitis Burden of Luminal Inflammation (DUBLIN) score or sub-components of these indices. A total of 33 studies evaluated the operating properties of the MES, UCEIS, and DUBLIN score in ASUC. The MES and the UCEIS demonstrated adequate discriminant construct validity, convergent construct validity, and responsiveness. Feasibility or reliability were not assessed for these scores. The DUBLIN score demonstrated indeterminate discriminant construct validity and convergent construct validity with limited data. Responsiveness, feasibility, and reliability were not assessed for this score.
Conclusions:
These results highlight the need for a validated endoscopic score that can accurately describe and quantify the severity of endoscopic lesions and potentially predict outcomes in ASUC patients.
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