Related Experiment Video
Updated: Sep 16, 2025

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
Edible beeswax-flaxseed oil nanostructured lipid carriers for improved β-sitosterol bioaccessibility: structural
Lukai Ma1, Zijian Li2, Linjing Li2
1Key Laboratory of Green Processing and Intelligent Manufacturing of Lingnan Specialty Food of Ministry and Rural Affairs, Guangdong Provincial Key Laboratory of Lingnan Specialty Food Science and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China; College of Light Industry and Food, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China.
Abstract:
This study developed nanostructured lipid carriers (NLCs) using edible beeswax and flaxseed oil to encapsulate β-sitosterol. Structural analysis revealed the formation of a less ordered lipid matrix with reduced crystallinity compared to pure beeswax, contributing to a high encapsulation efficiency of 92 %. Optimal formulation (beeswax: flaxseed oil 3:2, Tween 80: Polyglycerol fatty acid(PGE) 4:1 totaling 7 % emulsifier) and processing parameters (10 min homogenization, 200 W ultrasonic power for 4 min) yielded stable nanoparticles maintaining physical stability for 40 days across varying pH and temperature. In vitro digestion demonstrated that the NLCs effectively protected β-sitosterol from gastric degradation and enabled controlled intestinal release, achieving significantly higher bioaccessibility (43.9 %) compared to free β-sitosterol (12.1 %). These results highlight beeswax-flaxseed oil NLCs as a promising delivery system for enhancing the bioaccessibility of hydrophobic bioactive in functional foods.
More Related Videos
Related Concept Videos
Lipid Absorption
These breakdown products bind with bile salts and lecithin to form micelles, which quickly pass between microvilli to come in close contact with the apical...
Lipid-Lowering Drugs: Statins and Miscellaneous Agents

