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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Thyroid function and viability after larynx-trachea-thyroid allotransplantation: a case series.

Liu Wang1,2, Mailudan Ainiwaer3, Qing Shao1,2

  • 1Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, Chengdu, 610041, China.

European Archives of Oto-Rhino-Laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
|July 12, 2025
PubMed
Summary

Thyroid dysfunction is common after larynx-trachea-thyroid allotransplantation, requiring vigilant monitoring. Thyroid allotransplantation is feasible and may be a viable option for select patients.

Keywords:
Case reportLaryngeal allotransplantationThyroid functionThyroid transplantation

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Area of Science:

  • Transplant Surgery
  • Endocrinology
  • Head and Neck Surgery

Background:

  • Larynx-trachea-thyroid allotransplantation is a complex multi-organ transplant.
  • Thyroid dysfunction is a known complication of organ transplantation.
  • Limited data exists on thyroid function post-laryngeal allotransplantation and thyroid allotransplantation feasibility.

Purpose of the Study:

  • To evaluate thyroid function and graft viability after larynx-trachea-thyroid allotransplantation.
  • To assess the feasibility of thyroid allotransplantation as part of this procedure.

Main Methods:

  • Retrospective analysis of three patients undergoing larynx-trachea-thyroid allotransplantation.
  • Perioperative and post-discharge monitoring of thyroid function via ultrasound, serology, and pathology.
  • Assessment of graft viability and immunological rejection.

Main Results:

  • One patient developed euthyroid sick syndrome (ESS).
  • Another patient experienced thyrotoxicosis (hyperthyroidism) due to Graves' disease in the donor graft, later showing lymphocytic thyroiditis.
  • The third patient had ESS and subclinical hypothyroidism.
  • All patients demonstrated good graft viability with no signs of rejection.

Conclusions:

  • Thyroid dysfunction is a frequent complication of larynx-trachea-thyroid allotransplantation.
  • Close monitoring of thyroid function is essential post-transplant.
  • Thyroid allotransplantation is a feasible procedure and a potential option for specific candidates.