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Updated: Sep 15, 2025
03:36
Development of Compendium for Esophageal Squamous Cell Carcinoma
Published on: April 12, 2024
533
Esophageal carcinosarcoma: A rare case report
Mahmoud Reza Kalantari1, Mohadeseh Karimi2, Ramin Mashoufi3
1Department of Pathology, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
International Journal of Surgery Case Reports
|July 13, 2025
Summary
Esophageal carcinosarcoma (ECS) is a rare, biphasic tumor. Surgical resection is the most effective treatment for this esophageal cancer.
Area of Science:
- Oncology
- Gastroenterology
Background:
- Esophageal carcinosarcoma (ECS) is a rare, biphasic malignant neoplasm characterized by both epithelial and mesenchymal components.
- ECS typically presents as a polypoid lesion in the esophagus.
Observation:
- A case of a 74-year-old woman with dysphagia is presented.
- Gastrointestinal endoscopy revealed a large ulcerative polypoid lesion in the distal esophagus.
- Microscopic examination confirmed a biphasic mesenchymal and epithelial malignant tumor consistent with carcinosarcoma.
Findings:
- Dysphagia is the most common presenting symptom of ECS.
- Immunohistochemistry is crucial for diagnosis, utilizing markers like CEA, EMA, and synaptophysin for carcinomatous elements, and desmin, p63, and vimentin for sarcomatous elements.
- ECS is a biphasic tumor.
Implications:
- Early diagnosis and surgical resection are critical for managing esophageal carcinosarcoma.
- Understanding the biphasic nature of ECS guides diagnostic and therapeutic strategies.
- Further research into ECS pathogenesis and treatment is warranted.
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