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Updated: Sep 15, 2025
A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies
Published on: July 28, 2020
Detailed Analysis of Prognostic Factors in Patients with Soft Tissue Sarcoma Undergoing Unplanned Excision
Hiroyuki Tsuchie1, Makoto Emori2, Shohei Murata3
1Department of Orthopedic Surgery, Akita University Graduate School of Medicine, Akita, Japan, tuchikiti@yahoo.co.jp.
Abstract:
Objectives: Unplanned excision (UE) of soft tissue sarcoma (STS) impacts recurrence and prognosis, influenced by various factors. However, few studies have thoroughly analyzed these patients. This study aimed to comprehensively evaluate prognostic factors in patients with STS who underwent UE.
Subject And Methods:
We retrospectively identified 62 patients with STS who underwent UE. Data on clinical information and detailed assessment were collected. Clinical data were evaluated as risk factors for overall survival, local recurrence, and distant metastases. Furthermore, associations of influencing factors and survival outcomes were analyzed.
Results:
Multivariate analysis identified consultation after local recurrence following previous surgery and histological high grade as significant predictors of poor prognosis (p = 0.0390 and p = 0.0282, respectively). Histological high grade was the only risk factor for distant metastasis (p = 0.0173). Kaplan-Meier curves demonstrated significant differences in overall survival based on the presence or absence of local recurrence at referral after UE (p = 0.0476, p = 0.0022). The use of local anesthetics in previous surgeries was the only risk factor for consultation after local recurrence.
Conclusion:
Referral after local recurrence after UE and histological high grade were poor prognostic factors. Physicians must be aware that patients with UE should be referred to specialists promptly.
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