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Familial Aggregation of Colorectal Polyps: Disentangling Surveillance Effects From Genetic Predisposition

Chenyang Dong1, Chengshuai Pang1, Zhigang Wei1

  • 1Department of Biliary and Pancreatic Surgery, First Hospital of Shanxi Medical University, Yingze Strict, Taiyuan, Shanxi, China.

Gastroenterology
|July 13, 2025
PubMed
Abstract

No abstract available in PubMed .

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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