Related Experiment Video

Updated: Sep 15, 2025

Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms
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Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms

Published on: January 25, 2018

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Key subunits of γ-secretase complex and breast cancer progression: biological function, regulation mode and

Ran Xu1, Xin Yang2, Kuo Yao1

  • 1Department of Pathology and Pathophysiology, School of Basic Medical Sciences, Shenyang Medical College, Shenyang 110034, China.

Biochimica Et Biophysica Acta. Reviews on Cancer
|July 13, 2025
PubMed

Insights

This review explores how γ-secretase subunits contribute to breast cancer (BC) progression and chemoresistance. Targeting these subunits offers potential new therapies for overcoming treatment resistance in BC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Breast cancer (BC) is a leading cause of cancer death in women.
  • Current treatments like chemotherapy face challenges due to emerging drug resistance.
  • The Notch signaling pathway is implicated in BC development and progression.

Purpose of the Study:

  • To review the structure-function relationships and interactions of key γ-secretase subunits.
  • To elucidate the role of γ-secretase subunits in breast cancer pathogenesis.
  • To discuss the potential of γ-secretase inhibitors for overcoming BC chemoresistance.

Main Methods:

  • Literature review focusing on γ-secretase subunits (PSEN1, PSEN2, PEN-2, NCSTN, APH-1).
  • Analysis of preclinical studies and clinical trials.
  • Examination of structure-function relationships and subunit interactions.

Main Results:

  • Detailed elucidation of γ-secretase subunit roles in BC progression.
  • Emphasis on the link between γ-secretase complex and BC pathogenesis.
  • Discussion of preclinical and clinical data regarding γ-secretase and BC.

Conclusions:

  • γ-secretase complex plays a significant role in breast cancer.
  • Targeting γ-secretase subunits presents a promising therapeutic strategy for chemoresistant breast cancer.
  • Further research into γ-secretase inhibitors is warranted for BC treatment.
Keywords:
APH-1Breast cancerNCSTNPEN-2PSENγ-secretase

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