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Related Experiment Video

Updated: Sep 15, 2025

Method of Studying Palatal Fusion using Static Organ Culture

Method of Studying Palatal Fusion using Static Organ Culture

Published on: September 19, 2015

Articulation-function-associated brain developmental changes in cleft lip and palate patients.

Wenjing Zhang¹, Zhongtian Guan², Lei Cao¹

¹Department of Rehabilitation Medicine, Xuanwu Hospital Capital Medical University, Beijing, China.

Brain Research Bulletin

|July 13, 2025

Summary

This summary is machine-generated.

Individuals with cleft lip and palate (CLP) show altered brain function impacting articulation. Age influences these brain changes, necessitating tailored rehabilitation strategies for children and adults with CLP.

Keywords:

Articulation disorder Cleft lip and palate Functional connectivity Graph theory Mediation effect

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Area of Science:

Neuroscience
Speech-Language Pathology
Medical Imaging

Background:

Articulation disorder is a common communication issue in individuals with cleft lip and palate (CLP).
Previous research explored structural and functional brain changes in CLP, but age-related functional alterations linked to articulation remain unclear.

Purpose of the Study:

To investigate age-related brain functional differences in CLP patients.
To correlate these brain function differences with articulation performance.

Main Methods:

Resting-state functional magnetic resonance imaging (fMRI) was used on 127 participants (CLP children, healthy children, CLP adults, healthy adults).
Voxel-based analysis, functional connectivity, and network topology were assessed.
Mediation analysis explored relationships between age, brain function, and articulation.

Main Results:

Significant differences in resting-state brain function were observed between CLP children and adults, particularly in areas for semantic processing and motor control.
CLP adults showed increased connectivity and enhanced network properties compared to controls.
Regional homogeneity in the left medial superior frontal cortex mediated the link between articulation and age.

Conclusions:

CLP patients exhibit altered brain functional synchronization, with adults showing more developed networks.
Age-specific differences underscore the need for tailored rehabilitation protocols for CLP patients.
Understanding these age-related brain changes can inform more effective treatment strategies.