Investigations on the ocular pharmacokinetics of bendazac in rabbits

The ocular pharmacokinetics of bendazac were studied in rabbits, following intravenous administration of bendazac lysine. The compound and its 5-hydroxyderivative were determined in different eye compartments and plasma by radioassay, using [14C]bendazac, and HPLC. The highest concentrations were found in the iris and in descending order in the ciliary body, retina, cornea, tears, aqueous humor, vitreous, and lens. The time course of concentrations in the plasma, aqueous and vitreous humor, ciliary body, and retina showed kinetics described by the exponential equation y = aebx with a half-life of 2.47, 4.56, 3.59, and 3.22 hr, respectively; in the lens the half-life was 17.77 hr.