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Advantages, progress, and future trends in oral medicated jellies/gels: Focus on adherence aspects
Xinyue Huang1, Yingying Mu1, Lan Shen1
1Engineering Research Center of Modern Preparation Technology of Traditional Chinese Medicine of Ministry of Education, Shanghai University of Traditional Chinese Medicine, No. 1200, Cai-Lun Road, Pudong District, Shanghai 201203, PR China; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, No. 1200, Cai-Lun Road, Pudong District, Shanghai 201203, PR China.
Abstract:
Poor medication adherence is a pervasive issue in oral administration. Oral medicated jellies/gels are semisolid formulations that leverage the advantages of both solid and liquid formulations and have a promising potential. They help to increase patient comfort, simplify the medication process, and improve the medication experience, thereby improving medication adherence and alleviating many common barriers to adherence. This review analyzes the advantages of oral jellies from the perspective of improving adherence and summarizes the current state of research on this dosage form at five levels: improved bioavailability, drug release, swallowability, palatability, and appearance appeal. Finally, we discuss future research directions for this formulation.
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